Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy
Neuro-Oncology2016Vol. 19(5), pp. now254–now254
Citations Over TimeTop 1% of 2016 papers
Cassie Kline, Nancy M. Joseph, James P. Grenert, Jessica Van Ziffle, Eric Talevich, Courtney Onodera, Mariam Aboian, Soonmee Cha, David R. Raleigh, Steve Braunstein, Joseph C. Torkildson, David Samuel, Michelle Bloomer, Alejandra G. de Alba Campomanes, Anuradha Banerjee, Nicholas Butowski, Corey Raffel, Tarık Tihan, Andrew W. Bollen, Joanna J. Phillips, W. Michael Korn, Iwei Yeh, Boris C. Bastian, Nalin Gupta, Sabine Mueller, Arie Perry, Theodore Nicolaides, David A. Solomon
Abstract
Our experience demonstrates the significant impact of molecular profiling on diagnosis and treatment of pediatric brain tumors and confirms its feasibility for use at the time of diagnosis or recurrence.
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