Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients
Neuro-Oncology Advances2021Vol. 3(1), pp. vdab013–vdab013
Citations Over TimeTop 10% of 2021 papers
Elisa Izquierdo, Paula Proszek, Giulia Pericoli, Sara Temelso, Matthew Clarke, Diana Carvalho, Alan Mackay, Lynley V. Marshall, Fernando Carceller, Darren Hargrave, Birgitta Lannering, Zdeněk Pavelka, Simon Bailey, Natacha Entz‐Werlé, Jacques Grill, Gilles Vassal, Daniel Rodriguez Gutierrez, Paul S. Morgan, Tim Jaspan, Angela Mastronuzzi, Maria Vinci, Michael Hubank, Chris Jones
Abstract
Tumor-specific DNA alterations are more readily detected in CSF than plasma. Although we demonstrate the potential of the approach to assessing tumor burden, our results highlight the necessity for adequate sample collection and approach to improve detection if plasma samples are to be used.
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