Performance of Repeated Measures of (1–3)-β-D-Glucan, Mannan Antigen, and Antimannan Antibodies for the Diagnosis of Invasive Candidiasis in ICU Patients: A Preplanned Ancillary Analysis of the EMPIRICUS Randomized Clinical Trial
Open Forum Infectious Diseases2021Vol. 8(3), pp. ofab080–ofab080
Citations Over TimeTop 24% of 2021 papers
Claire Dupuis, Clément Le Bihan, Danièle Maubon, Laure Calvet, Stéphane Ruckly, Carole Schwebel, Lila Bouadma, Élie Azoulay, Muriel Cornet, Jean‐François Timsit, Empiricus Study Group, Rébecca Hamidfar-Roy, M. Ciroldi, Clichy Catherine Paugam-Burtz, Arnaud Foucrier, Jean Christophe Navellou, Michel Wolff, Jean‐François Timsit, Lila Bouadma, Bruno Mourvillier, Romain Sonneville, Sarah Chemam, Didier Gruson, Bertrand Souweine, Alexandre Lautrette, Pierre‐Emmanuel Charles, Rémi Bruyère, Maël Hamet, Bernard Allaouchiche, C. Guillaumé, Charles-Éric Ber, J. Prothet, Thomas Rimmelé, Laurent Argaud, Marie Simon, Martin Cour, Romain Hernu, Samir Jaber, Boris Jung, Mathieu Conseil, Yannaël Coisel, Fouad Belafia, Kada Klouche, Laurent Amigues, Sônia Salgueiro Machado, Marianne Serveaux, Jean Chastre, Jean‐Louis Trouillet, Joël Cousson, P Raclot, Thierry Floch, Fabrice Zéni, Michaël Darmon, Matthias Pichon, M. Coudrot, Sebastien Ninet, Éric Diconne, Benoı̂t Schlemmer, Élie Azoulay, Virginie Lemiale, Nicolas Maziers, Ferhat Meziani, David Schnell, Julie Helms, Raluca Neagu-Anca, Xavier Delabranche, Olivier Martinet, Maïté Garrouste-Orgeas, Benoît Misset, Fabrice Brunee, Virginie Laurent, Guillaume Lacave, Jean‐Pierre Bédos, Khadija Hammi, Lenka Styfalova, J. Fritzsch, Sophie Letrou, Lucie Estevez, Therese Devaux, Celine Dubien, Soumia Bayarassou, Catherine Jouvene Faure, Sylvie de La Salle, Albert Prades, A. Rodríguez, Pierre Meur, Magda Warchol, Hanane El Haouari, Igor Theodose, Julien Fournier, Sébastien Cavelot, Lilia Bakir Kodja, Marie Joyeux‐Faure, Frédéric Tacco, Sonia Roos, Karima Dupre, Malek Abazid, Michele Essert, Philippe Arnaud, Emmanuelle Papy, Bellabes Ghezzoul, Olivier Gerbouin, Sandrine Corny Peccoux, Philippe Fagnoni, Anne Millaret, C. Pivot, C. Gérard, Cyril Breuker, Audrey Castet, Fanny Charbonnier, Maryline Legrand, Julia Mordini, Isabelle Madeleine Chambrin, Anne Hutt Clauss, Mohamed Cherifi, Anne Pattyn, Murielle Cornet, Danièle Maubon, E Benveniste, Fréderic Grenouillet, Christian Chochillon, Isabelle Accoberry, Denis Pons, Natacha Mrozek, Frédéric Dalle, Stéphane Picot, Beyerle Françoise, Anne‐Lise Bienvenu, Nathalie Bourgeois, Arnaud Fekkar, D. Toubas, H. Rabérin, Ermanno Candolfi, Valérie Bru‐Adan, Marie Dominique Kitzis, Yaye Senghor, Catherine Palette, Stéphane Ruckly, Aurélien Vesin, Jean-Paul Mira, Jean-Ralph Zahar, Dominique Larrey, Jean‐Pierre Zarski, Jean-Ralph Zahar, Jean-Paul Mira, Dominique Larrey, Jean‐Pierre Zarski, Edith Schir
Abstract
Among high-risk patients, a first measurement of BDG >80 pg/mL was strongly associated with the occurrence of IC. Neither a cutoff of 250 pg/mL nor repeated measurements of fungal biomarkers seemed to be useful to predict the occurrence of IC. The cumulative risk of IC in the placebo group if BDG >80 pg/mL was 25.39%, which calls into question the efficacy of empirical therapy in this subgroup.
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