Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases
European Journal of Gastroenterology & Hepatology2006Vol. 18(6), pp. 615–621
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Jürgen Schauber, Daniel Rieger, Frank Weiler, Jan Wehkamp, Matthias Eck, Klaus Fellermann, W Scheppach, Richard L. Gallo, Eduard F. Stange
Abstract
In IBD the colonic expression of human cathelicidin is altered: cathelicidin expression is increased in inflamed and non-inflamed mucosa in patients suffering from ulcerative colitis but not in Crohn's disease. This deficiency may further compromise the antimicrobial barrier in Crohn's disease.
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