Abnormal permeability of inner and outer mitochondrial membranes contributes independently to mitochondrial dysfunction in the liver during acute endotoxemia*
Critical Care Medicine2004Vol. 32(2), pp. 478–488
Citations Over TimeTop 10% of 2004 papers
Elliott D. Crouser, M Julián, Jennifer E. Huff, Mandar Joshi, John Anthony Bauer, Martha E. Gadd, Mark D. Wewers, Douglas R. Pfeiffer
Abstract
These studies confirm that liver mitochondria are early targets of injury during endotoxemia and that inner and outer mitochondrial membrane damage occurs through different mechanisms. Inner mitochondrial membrane damage appears to relate to the mitochondrial permeability transition, whereas outer mitochondrial membrane damage can occur independent of the mitochondrial permeability transition. Preliminary evidence suggests that Bax may participate in lipopolysaccharide-induced outer mitochondrial membrane damage, but further investigations are needed to confirm this.
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