Carbamoyl phosphate synthase-1: A marker of mitochondrial damage and depletion in the liver during sepsis
Critical Care Medicine2006Vol. 34(9), pp. 2439–2446
Citations Over TimeTop 10% of 2006 papers
Abstract
Circulating CPS-1 is a marker of mitochondrial damage and depletion in the liver during the subacute phase of CLP sepsis. From a mechanistic standpoint, mitochondrial depletion is not due to cell death but is apparently related to the removal of damaged mitochondria by lysosomes (i.e., autophagy), followed by repletion of mitochondrial populations. Further studies are needed to determine the clinical utility of CPS-1 as a marker of sepsis severity.
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