IMPACT OF 60 DAY OF BEDREST ON LONG-TERM PULSE WAVE VELOCITY EVOLUTION

Citations Over Time

Abstract

Objective: Pulse Wave Velocity (PWV) reflects aortic stiffness. High arterial stiffness is a proxy for early vascular aging and an independent predictor of cardiovascular risk. We tested whether Head Down Bedrest protocol, an on-earth simulation of microgravity, could affect arterial stiffness, and whether recovery could be measured at short, medium and long term after return to orthostatism. We aim to describe the evolution of pulse wave velocity during 60 days of bedrest, and 1 week, 4 weeks and 52 weeks after. Design and method: Twenty healthy males without cardiovascular risks or disease were selected for Bedrest study. PWV were assessed with sphygmocor by experienced investigators 6 time during our study: one measure at baseline, 2 measures during bedrest phase and 3 measures at recuperation phase (in 11 subjects at 52 Weeks). PWV evolution was analyzed with a mixed model, adjusted on mean blood pressure (MBP). Results: We observed a significant increase of PWV during bedrest phase compared to baseline, with an average increase of 1.58 m/s (p < 0,001), after adjustment on MBP. All subjects increased PWV. The increase in PWV was significant right after bedrest phase (average increase of 0,73 m/s compared to baseline (p = 0,02), and did not regress more after one month. The increased in PWV was still significant one year after bedrest phase (+ 0,78 m/s (p = 0,03) after adjustment on MBP). One year after bedrest protocol, none of our patients’ PWV value has gone back to baseline value. Conclusions: Our study showed an important, significant increase of pulse wave velocity during and after bedrest study. These modifications were observed one year after bedrest study, which suggests that prolonged bedrest conditions induce early vascular aging and increase the global cardiovascular risk of patient.

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