Prolonged Time to Surgery After Neoadjuvant Chemoradiotherapy Increases Histopathological Response Without Affecting Survival in Patients With Esophageal or Junctional Cancer
Annals of Surgery2014Vol. 260(5), pp. 807–814
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Joël Shapiro, Pieter van Hagen, Hester F. Lingsma, Bas P. L. Wijnhoven, Katharina Biermann, Fiebo J.W. ten Kate, Ewout W. Steyerberg, Ate van der Gaast, J. Jan B. van Lanschot
Abstract
Prolonged TTS after nCRT increases the probability of pCR and is associated with a slightly increased probability of postoperative complications, without affecting disease-free and overall survivals. We conclude that TTS can be safely prolonged from the usual 4 to 6 weeks up to at least 12 weeks, which facilitates a more conservative wait-and-see strategy after neoadjuvant chemoradiotherapy to be tested.
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