Photocontrol of endogenous glycine receptors in vivo
bioRxiv (Cold Spring Harbor Laboratory)2019
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Alexandre M. J. Gomila, Karin Rustler, Galyna Maleeva, Alba Nin‐Hill, Daniel Wutz, Antoni Bautista-Barrufet, Xavier Rovira, Miquel Bosch, Elvira Mukhametova, Marat A. Mukhamedyarov, Frank Peiretti, Mercedes Alfonso‐Prieto, Carme Rovira, Burkhard König, Pìotr Bregestovski, Pau Gorostiza
Abstract
ABSTRACT Glycine receptors (GlyRs) are indispensable to maintain excitatory/inhibitory balance in neuronal circuits controlling reflex and rhythmic motor behaviors. Here we have developed Glyght, the first GlyR ligand controlled with light. It is selective over other cys-loop receptors, active in vivo , and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understand inhibitory circuits in intact animals, and to develop drug-based phototherapies.
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