Transposon-Induced Hotspots for Genomic Instability
Citations Over Time
Abstract
Although the potential of transposable elements (TEs) to produce genomic rearrangements, such as inversions and translocations, has been appreciated for some time from the results of laboratory experiments, estimates of the frequency and evolutionary importance of such events in natural populations have been difficult to come by. Now, with the ability to obtain nucleotide sequence data on a large scale, we are starting to learn about the nature and frequency of TE-induced changes in the structure of their host genomes. Not only is direct evidence being provided to support predictions that TEs can initiate chromosomal rearrangements by ectopic recombination and other mechanisms, but surprising examples of massive local genomic instability are being reported that were not predicted by earlier models of TE behavior. In this issue, a remarkable example of an unprecedented degree of genome restructuring is reported in a study of the breakpoints of a TE-induced inversion in Drosophila buzzatii (Caceres et al. 2001).
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