Gamma‐Aminobutyric Acid System Genes—No Evidence for a Role in Alcohol Use and Abuse in a Community‐Based Sample
Alcoholism Clinical and Experimental Research2014Vol. 38(4), pp. 938–947
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Daniel E. Irons, William G. Iacono, William S. Oetting, Robert M. Kirkpatrick, Scott Vrieze, Michael B. Miller, Matt McGue
Abstract
These results reflect alcohol-related behaviors in a population-representative sample, many of whom are still in adolescence, and in which the incidence of heavy drinking and alcohol-related symptomatology are relatively low. Contrasted with existing studies of the association between alcohol use and GABA system genes, our results suggest that the relationship may be limited to particular contexts, such as when accompanied by polysubstance abuse or a familial history of alcoholism.
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