Small-Fiber Degeneration in Alcohol-Related Peripheral Neuropathy
Alcoholism Clinical and Experimental Research2014Vol. 38(7), pp. 1965–1972
Citations Over TimeTop 14% of 2014 papers
Michelle Mellion, Elizabeth Silbermann, James M. Gilchrist, Jason T. Machan, Lorenzo Leggio, Suzanne de la Monte
Abstract
ALN is associated with a small-fiber neuropathy that can be detected with skin biopsy in heavy alcohol drinking individuals with normal thiamine status. Skin biopsy is a useful, minimally invasive biomarker that could extend studies to understand the effect of alcohol on the peripheral nerves and to evaluate potential therapeutic agents in larger clinical trials.
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