Areas of controversy in neuroprogression in bipolar disorder
Acta Psychiatrica Scandinavica2016Vol. 134(2), pp. 91–103
Citations Over TimeTop 1% of 2016 papers
Abstract
Illness trajectories are largely variable, and illness progression is not a general rule in BD. The number of manic episodes seems to be the clinical marker more robustly associated with neuroprogression in BD. However, the majority of the evidence came from cross-sectional studies that are prone to bias. Longitudinal studies may help to identify signatures of neuroprogression and integrate findings from the field of neuroimaging, neurocognition, and biomarkers.
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