Identification of Maillard reaction products on peanut allergens that influence binding to the receptor for advanced glycation end products
Allergy2013Vol. 68(12), pp. 1546–1554
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Geoffrey A. Mueller, Soheila J. Maleki, Kenneth L. Johnson, Barry K. Hurlburt, Heng Cheng, Sanbao Ruan, Jacqueline B. Nesbit, Anna Pomés, Laura Edwards, Allison N. Schorzman, Leesa J. Deterding, Hae‐Sim Park, K. B. Tomer, Robert E. London, Jason G. Williams
Abstract
AGE modifications to Ara h 1 and Ara h 3 can be found in both raw and roasted peanuts. Receptor for AGE was demonstrated to selectively interact with AGE-modified rAra h 1. If sensitization to peanut allergens occurs in dendritic cells via RAGE interactions, these cells are likely interacting with modified Ara h 1 and Ara h 3, but not Ara h 2.
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