Epicutaneously applied Der p 2 induces a strong TH2‐biased antibody response in C57BL/6 mice, independent of functional TLR4
Allergy2014Vol. 69(6), pp. 741–751
Citations Over TimeTop 11% of 2014 papers
Caroline Stremnitzer, Krisztina Manzano-Szalai, Philipp Starkl, Anna Willensdorfer, S. Schrom, Josef Singer, Ursula Reichart, Shizuo Akira, Erika Jensen‐Jarolim
Abstract
Our data suggest that rDer p 2 alone can cause a strong TH 2-biased response via the skin being enhanced in the presence of LPS. This response is not reliant on functional TLR4, but vice versa TLR4 expression rather protects against epicutaneous sensitization to house dust mite allergen Der p 2.
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