IL‐33 drives airway hyper‐responsiveness through IL‐13‐mediated mast cell: airway smooth muscle crosstalk
Allergy2015Vol. 70(5), pp. 556–567
Citations Over TimeTop 10% of 2015 papers
Davinder Kaur, E. Gomez, Camille Doe, Rachid Berair, Lucy Woodman, Ruth Saunders, Fay Hollins, Felicity R. A. J. Rose, Yassine Amrani, Richard May, Jennifer Kearley, AA Humbles, E. Suzanne Cohen, Christopher E. Brightling
Abstract
IL-33 directly promotes mast cell activation and ASM wound repair but indirectly promotes ASM contraction via upregulation of mast cell-derived IL-13. This suggests that IL-33 may present an important target to modulate mast cell-ASM crosstalk in asthma.
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