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Paving the way of systems biology and precision medicine in allergic diseases: the Me DALL success story

Allergy2016Vol. 71(11), pp. 1513–1525

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Jean Bousquet, Josep M. Antó, Mübeccel Akdiş, Charles Auffray, Thomas Keil, Isabelle Momas, Dirkje S. Postma, Rudolf Valenta, Magnus Wickman, Anne Cambon‐Thomsen, Tari Haahtela, Bart N. Lambrecht, Kai‐Håkon Carlsen, Gerard H. Koppelman, Jordi Sunyer, Torsten Zuberbier, Isabella Annesi‐Maesano, A. Arno, Carsten Bindslev‐Jensen, G. De Carlo, Francesco Forastiere, Joachim Heinrich, M. L. Kowalski, D. Maier, Erik Melén, S. Palkonen, Henriëtte A. Smit, Marie Standl, John Wright, Anna Asarnoj, Marta Benet, Natalia Ballardini, Judith García‐Aymerich, Ulrike Gehring, Stefano Guerra, C. Hohman, Inger Kull, Christian Lupinek, Mariona Pinart, I. Skrindo, Marit Westman, Delphine Smagghe, Cezmi A. Akdiş, Richard Albang, Velizara Anastasova, Naomi M. Anderson, Claus Bachert, Stéphane Ballereau, Ferrán Ballester, Xavier Basagaña, Anna Bedbrook, Anna Bergström, Andrea von Berg, Bert Brunekreef, Emilie Burte, Kai Håkon Carlsen, L. Chatzi, Jonathan M. Coquet, Mirela Curin, Pascal Demoly, Esben Eller, Maria Pia Fantini, Beatrix Gerhard, Hamida Hammad, Leena C. von Hertzen, Vegard Hovland, Bénédicte Jacquemin, J. Just, Theresa Keller, Marjan Kerkhof, Renáta Kiss, Manolis Kogevinas, Sibylle Koletzko, Susanne Lau, Irina Lehmann, Nicolas Lemonnier, Rosemary McEachan, Mika J. Mäkelä, Jordi Mestres, E.S. Minina, Petter Mowinckel, Rachel Nadif, Martijn C. Nawijn, Sam Oddie, J. Pellet, Isabelle Pin, Daniela Porta, Fanny Rancière, A. Rial-Sebbag, Yvan Saeys, Martijn J. Schuijs, Valérie Siroux, Christina Tischer, M. Torrent, Raphaëlle Varraso, Joke De Vocht, Karsten Wenger, Sandra Wieser, Cheng‐Jian Xu

Abstract

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

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Abstract

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