High-dose bee venom exposure induces similar tolerogenic B-cell responses in allergic patients and healthy beekeepers
Allergy2016Vol. 72(3), pp. 407–415
Citations Over TimeTop 10% of 2016 papers
Tadech Boonpiyathad, N. Meyer, Marcin Moniuszko, Milena Sokołowska, Andrzej Eljaszewicz, Oliver F. Wirz, Maria Magdalena Tomasiak, Anna Bodzenta‐Łukaszyk, Kiat Ruxrungtham, Willem van de Veen
Abstract
This study provides the first detailed characterization of allergen-specific B cells before and after bee venom tolerance induction. The observed B-cell responses in both venom immunotherapy-treated patients and naturally exposed beekeepers suggest a similar functional immunoregulatory role for B cells in allergen tolerance in both groups. These findings can be investigated in other AIT models to determine their potential as biomarkers of early and successful AIT responses.
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