Myeloid-derived suppressor cell-like fibrocytes are increased and associated with preserved lung function in chronic obstructive pulmonary disease
Allergy2016Vol. 72(4), pp. 645–655
Citations Over TimeTop 12% of 2016 papers
Adam Wright, Chris Newby, Ruth Hartley, Vijay Mistry, Sumit Gupta, Rachid Berair, Katy M. Roach, Ruth Saunders, Tracy Thornton, M. Shelley, K Edwards, Bethan Barker, Christopher E. Brightling
Abstract
We have demonstrated that two circulating populations of fibrocyte exist in COPD, with distinct clinical associations, but are not prevalent in proximal or small airway tissue. Blood MDSC-like fibrocytes, however, are increased and associated with preserved lung function through a small airway-dependent mechanism in COPD.
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