Nonlesional atopic dermatitis skin shares similar T‐cell clones with lesional tissues
Allergy2017Vol. 72(12), pp. 2017–2025
Citations Over TimeTop 10% of 2017 papers
Patrick M. Brunner, Ryan Emerson, Christopher M. Tipton, Sandra Garcet, Saakshi Khattri, Israel Coats, James G. Krueger, Emma Guttman‐Yassky
Abstract
While AD harbors a highly polyclonal T-cell receptor repertoire, and despite the lack of information on TCR antigen specificity, the sharing of top abundant clones between lesional and nonlesional skin, and their persistence after months of therapy, points to the continuous presence of potentially pathogenic skin resident memory T cells well beyond clinically inflamed lesions.
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