Type 2/Th2‐driven inflammation impairs olfactory sensory neurogenesis in mouse chronic rhinosinusitis model
Allergy2018Vol. 74(3), pp. 549–559
Citations Over TimeTop 15% of 2018 papers
Angéla Rouyar, Marion Classe, Raphael Gorski, Marie‐Dominique Bock, Joelle Le‐Guern, Sandrine Roche, Valerie Fourgous, Anne Rémaury, Pascal Paul, Clara Ponsolles, Dominique Françon, Laurence Rocheteau‐Beaujouan, Margerie Clément, El‐Bdaoui Haddad, Jean‐Claude Guillemot, Michel Didier, Bruno Biton, Cécile Orsini, Vincent Mikol, Maud Leonetti
Abstract
Our mouse model of CRS displayed an allergic response to HDM + SEB administration, including the type 2/Th2 inflammatory profile characteristic of human eosinophilic CRSwNP. Although the sense of smell did not appear to be altered in these conditions, the data reveal the influence of chronic inflammation on olfactory neurogenesis, suggesting that factors unique to humans may be involved in CRSwNP-associated anosmia.
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