IgG4 drives M2a macrophages to a regulatory M2b‐like phenotype: potential implication in immune tolerance
Allergy2018Vol. 74(3), pp. 483–494
Citations Over TimeTop 10% of 2018 papers
Rodolfo Bianchini, Franziska Roth‐Walter, Anna Ohradanova‐Repic, Sabine Flicker, Karin Hufnagl, Michael B. Fischer, Hannes Stockinger, Erika Jensen‐Jarolim
Abstract
Immune complexes with subclasses IgG1 and IgG4 can in vitro be generated by plate absorption, and in fluid form by protein L. Cross-linking of FcγRIIb by the IgG4 subclass redirects pro-allergic M2a macrophages to an M2b-like immunosuppressive phenotype. This suggests an interplay of macrophages with IgG4 in immune tolerance, likely relevant in allergen immunotherapy.
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