The hippo pathway effector Yes‐associated protein promotes epithelial proliferation and remodeling in chronic rhinosinusitis with nasal polyps
Allergy2018Vol. 74(4), pp. 731–742
Citations Over TimeTop 15% of 2018 papers
Huiyi Deng, Yueqi Sun, Wei‐hao Wang, Meijiao Li, Yuan Tian, Weifeng Kong, Xuekun Huang, Zi‐Jie Long, Zhuang‐Gui Chen, De Yun Wang, Qintai Yang
Abstract
Hippo pathway components are abnormally upregulated in NPECs, and its effector YAP promotes nasal epithelial cells proliferation and remodeling in CRSwNP. It provides a rationale to explore inhibition of YAP as a novel therapeutic strategy for reducing the epithelial proliferation and remodeling in CRSwNP.
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