Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity
Allergy2019Vol. 74(12), pp. 2382–2393
Citations Over TimeTop 10% of 2019 papers
Wai Tuck Soh, Lorenz Aglas, Geoffrey A. Mueller, Stefanie Gilles, Richard Weiss, Sandra Scheiblhofer, Sara Huber, Tamara Scheidt, Peter M. Thompson, Peter Briza, Robert E. London, Claudia Traidl‐Hoffmann, Chiara Cabrele, Hans Brandstetter, Fátima Ferreira
Abstract
Bet v 1 can serve as a transporter of pollen-derived, bioactive compounds. When carried to the endolysosome, such compounds can modulate the proteolytic activity, including its processing by cysteine cathepsins. We unveil a paradigm shift from an allergen-centered view to a more systemic view that includes the host endolysosomal enzymes.
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