Handling of allergen immunotherapy in the COVID‐19 pandemic: An ARIA‐EAACI statement

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Abstract

The current COVID-19 pandemic influences many areas of social life, medical treatments and the way allergy diagnosis and treatment is performed. Allergen-specific immunotherapy (AIT) is one of the most important treatment options for IgE-mediated allergies and is based on immunological effects on the diseased patient. This manuscript outlines the EAACI recommendations regarding AIT during the COVID-19 pandemic and aims at supporting allergists and all physicians performing AIT in their current daily practice with clear recommendations how to perform treatment during the pandemic and in SARS-CoV-2 infected patients. The World Health Organization (WHO), on March 11, 2020, declared a pandemic of an infectious disease recently referred to as “coronavirus disease 2019” (COVID-19). Currently, COVID-19 is fast spreading across the globe. COVID-19 is caused by a novel strain of human coronaviruses, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), named by the International Committee on Taxonomy of Viruses (ICTV). SARS-CoV-2 was first detected in a cluster of patients with pneumonia in December 2019 in Wuhan, China.1, 2 SARS-CoV-2 is a Betacoronavirus of the subgenus Sarbecovirus and the subfamily Orthocoronavirinae. It can be isolated from human samples obtained from respiratory secretions, nasal and pharyngeal smears and isolated on cell cultures.1, 2 SARS-CoV-2 is the 7th member of the coronavirus family able to infect humans. It differs from the Middle East respiratory syndrome coronavirus (MERS-CoV), the severe acute respiratory syndrome coronavirus (SARS-CoV), and viruses responsible for the common cold (229E, OC43, NL63, and HKU1).3 Coronaviruses are zoonotic, that is, they can be transmitted between animals and humans. COVID-19 presents with many different clinical manifestations, ranging from asymptomatic cases to mild and severe disease, with or without pneumonia.4 Common signs of COVID-19 are respiratory problems, fever, cough, shortness of breath, and difficulties in breathing. Other signs of viral airway infection may include nasal symptoms and sore throat. In more severe cases, infection with COVID-19 can cause pneumonia, severe acute respiratory syndrome, kidney failure, and even death.4-8 In published scientific literature on COVID-19, higher age, chronic respiratory diseases, diabetes mellitus, coronary artery disease, and immunodeficiency of different origins are listed as risk factors for severe illnesses, hospitalization, and death.4-6, 8 As COVID-19 is caused by a newly identified viral strain, there are no therapeutics proved to be effective in clinical trials or vaccines, so far, and there is presumed to be no pre-existing immunity in the population.9 In most instances, coronaviruses are believed to be transmitted through large respiratory droplets from person to person, through inhalation or deposition on mucosal surfaces. Other routes implicated in the transmission of coronaviruses include contact with contaminated fomites and inhalation of aerosols produced during aerosol-generating procedures, such as sneezing or coughing. The SARS-CoV-2 virus has been detected in respiratory, fecal, and blood specimens.10 The highest risk of healthcare-associated transmission occurs in the absence of standard precautions, when primary infection prevention and control measures for respiratory infections are not in place, and when handling patients whose COVID-19 diagnoses is yet to be confirmed. Since airborne transmission is possible, we recommend a cautious approach because of possible transmission through aerosols.11, 12 More disease background information is available online from the European Centre for Disease Prevention and Control (ECDC),13 WHO,14 and the ECDC’s Rapid Risk Assessment.9 AIT is the only disease-modifying therapy that confers a long-term clinical benefit for allergic airway diseases such as in allergic bronchial asthma or allergic rhinoconjunctivitis and other allergic conditions.15 Since its16emergence over hundred years ago (1911), AIT is an established and internationally recognized procedure for the causal treatment of immediate-type allergic reactions (type I allergy) and associated diseases. AIT induces an immune tolerance responses against the allergen in sensitized patients.17 Systematic reviews and meta-analyses have confirmed that AIT is effective in reducing symptoms together with rescue medication in patients with allergic asthma 18 and allergic rhinoconjunctivitis.19 This applies to both, subcutaneous immunotherapy (SCIT)20, 21 and sublingual immunotherapy (SLIT), liquid drops or tablets placed under the tongue.22 The reduced risk of developing asthma in patients with allergic rhinitis is another advantage of AIT, that is still under debate but was demonstrated to be at least effective in the short term.23, 24 AIT is also effective in patients with IgE-mediated food allergy 23-26 and insect venom allergy.27 Moreover, analyses by the European Academy of Allergy and Clinical Immunology (EAACI) demonstrated the cost-effectiveness of this disease-modifying therapy option.28-30 Eventhough it is well established that allergic airway diseases are associated with an increased risk of infections, little is known about the potential influence of viral infections on AIT.31 In a prospective and comparative clinical study, Ahmetaji et al found no significant difference in the efficacy or in the improvement of symptoms of allergic asthma patients under subcutaneous allergen-specific immunotherapy with or without symptomatic influenza, nor in the standard chemical and hematology parameters and different cytokines during a one-year follow-up.32 These preliminary data suggest that SCIT in influenza-infected patients was safe and well-tolerated. Iemoli et al. evaluated the safety and clinical effectiveness of sublingual grass tablet immunotherapy in a group of HIV-positive patients with allergic rhinitis under antiretroviral HIV therapy. HIV infection has been regarded to be a relative contraindication for AIT. Highly active antiretroviral treatment has improved the immune function and life expectancy in HIV-infected patients whose respiratory allergic incidence is similar to that of the general population.33 Clinical efficacy data showed a significant improvement in SLIT-treated patients compared to controls but not any considerable alteration of peripheral T CD4 lymphocyte cell counts and HIV viral load in both group. These data show that SLIT therapy in viro-immunological controlled HIV-positive patients was efficacious, safe, and well-tolerated. Cytomegalovirus (CMV) was shown to enhance the allergenic potential of otherwise poorly allergenic environmental protein antigens ina mouse model of airway co-exposure to CMV and ovalbumin (OVA).34 In contrast, immune reactions to virus-like-particles (Vlp) may enforce the immune responses in AIT and may even be used as AIT adjuvants for inhalational and food (peanut) allergen in the near future.35, 36 With the limited experimental data available so far, it seems that patients with allergic rhinitis did not develop additional distinct symptoms and more severe courses than other patients.4 Allergic children showed a mild course, similar to other children.4 AIT aims to induce allergen-specific immune tolerance in allergy patients by using multiple mechanisms including T cells, B cells, innately lymphoid cells (ILC), and effector cells, such as eosinophils, mast cells, and basophils. One of the main changes is the development of a T and B regulatory cell response and their suppressive cytokines such as IL-10 and TGF-β and surface molecules such as CTLA-4 and PD1, all of which form a suppressive milieu.29, 37 This immune regulatory response is taking place in targeted antigen-/allergen-specific T and B cells but does not affect the whole immune system and does not cause any systemic immune deficiency. T-cell responses in severe COVID-19 are represented with lymphopenia that is mainly affecting memory T lymphocytes. Both CD4 and CD8 T cells decrease; however, this change is more pronounced in CD8 + T cells. Cytotoxic T lymphocytes and NK cells in patients infected with SARS-CoV-2 are essential for an appropriate anti-viral response.38 A recent study suggests that patients show functional exhaustion of cytotoxic T lymphocytes associated with SARS-CoV-2 infection. The total number of NK and CD8 + T cells was markedly decreased in patients with SARS-CoV-2 infection.38 This may cause a disruption of anti-viral immunity and may play a role in the pathogenesis and severity of COVID-19. AIT significantly decreases allergen-specific Th2 cells in circulation and reduces the general type2 response by decreasing Th2 cells and type 2 ILCs.39-41 COVID-19 does not significantly increase in severity in allergic patients, with conditions such as rhinitis, urticaria, and atopic dermatitis.4, 42 It has not been demonstrated if there is a switch between TH1 and TH2 cells in COVID-19, but there are developing data that disease severity is linked to a systemic Th1 response and inflammasome activation together with a cytokine storm. Similar to SARS and MERS, a cytokine storm is a common feature of severe COVID-19 cases and a major reason for acute respiratory distress syndrome (ARDS) and multi organ failure. Several levels of evidence suggest that the rapid COVID-19 mortality might be due to a virus-activated “cytokine storm syndrome”.43 In a study of 41 hospitalized patients with high levels of proinflammatory cytokines including IL-2, IL-7, IL-10, G-CSF, IP-10, MCP-1, MIP-1A, and TNFα were observed in severe COVID-19 cases.44 AIT changes the cellular composition and inflammatory mediators in the affected organs, such as for example the nose in allergic rhinitis.17 Eosinophils and their inflammatory mediators decrease in allergic rhinitis in the nose during AIT. In COVID-19, systemic eosinopenia was observed in 52.9% of the patients. Decreased blood eosinophil counts correlate positively with lymphocyte counts in severe (r = 0.486, P < .001) and nonsevere (r = 0.469, P < .001) patients after hospital admission.4 The reasons and mechanisms of systemic eosinopenia remain to be investigated. In AIT, reduced eosinophil counts and regulation of specific TH2 response is only seen after several years of continues therapy. This supports that AIT is not going to interfere viral infections. AIT has a clear desensitization effect on effector cells. This effect is antigen specific and is acting early during the course of AIT. Mast cells are not considered to be relevant in viral infection response. Allergen-specific antibody levels change in the course of AIT with decreased specific IgE in the long run and a relatively rapid increase in specific IgG1 and IgG4.29, 45 In COVID-19 like many viral infections, SARS-CoV-2-specific IgM increases in the acute phase followed by specific IgG.46-48 Overall, theCOVID-19 immunological mechanisms seem to be similar to SARS and MERS and also to severe influenza infections. An appropriate anti-viral immune response should develop with cytotoxic T cells and IgM and IgG antibodies, whereas a very strong uncontrolled immune response as in a cytokine storm becomes detrimental (Table 1). We recommend using the infection prevention and control measures in any patient undergoing AIT according to ECDC and WHO. This implies that the recommended infection prevention and control measures of individual regions or countries should be followed, including those in this document and the procedures for reporting and transfer of persons under investigation and of probable/confirmed COVID-19 cases. Those feeling ill with typical respiratory symptoms should be encouraged to contact healthcare services by telephone or E-Health/telemedicine/online to seek medical advice 13, 49(triage). This will reduce the number of people with symptoms of COVID-19 that have contact with the Allergy center healthcare personnel.13, 49 Allergy services and primary care staff, including physicians, nursing, and administrative staff with patient contact, should be aware of the following: (a) the current COVID-19 epidemiologic situation in their country and globally; (b) known risk factors for infections; (c) clinical symptoms and signs of COVID-19; (d) recommended infection prevention and control measures in their region or country, including those in this document; and (e) procedures for reporting and transfer of persons under investigation and of probable/confirmed cases. Appropriate personal protective equipment (PPE) should be available onsite for all personnel at the point-of-care to provide standard, contact, and droplet protection. In each Allergy facility, a dedicated member of staff (eg, head doctor/nurse) should lead the COVID-19 preparedness and implement relevant infrastructure and control measure policies. Signs should be posted at all entrance doors listing the main symptoms compatible with COVID-19 (fever, cough, and shortness of breath) and informing visitors with any of these symptoms not to enter the Allergy Unit. Everyone within the Allergy clinic and all those entering the practice should adopt appropriate hand hygiene measures, using soap and water, or an alcohol-based handrub. Based on a case-by-case risk assessment, the use of PPE for AIT should be considered. With the current knowledge on the transmission of COVID-19, in which respiratory droplets seem to play a significant role (although airborne transmission cannot be ruled out at this stage), and taking into consideration the possible shortage of PPE in healthcare settings due to the increasing number of COVID-19 patients, the suggested set of PPE for droplet, contact, and airborne transmission (gloves, goggles, gown, and FFP2/FFP3 respirator) can be adapted for the clinical assessment of suspected COVID-19 cases. If available, provide a surgical mask for patients with respiratory symptoms (eg, cough).50 Healthcare workers performing aerosol-generating procedures (AGP), such as swabbing,50 should wear the suggested PPE set for the prevention of droplet, contact, and airborne transmission (gloves, goggles, gown, and FFP2/FFP3 respirator).51 To maximize the use of PPE if there is an insufficient supply, staff should be assigned to carry out procedures, or a procedure, in designated areas.52 AIT is a treatment that requires recurrent doctor/nurse/patient contact over a more extended period, for example, 3 years. In SCIT, injections are administered with daily, weekly (up dosing phase), or monthly (continuation phase) intervals. In SLIT, the initiation is given in allergy clinics or in a doctor´s office, while continuation is performed by patients themselves with regular control visits. Each SCIT or SLIT product needs approval by the competent authority. It must contain information on how to use the AIT product for patients, allergologists, and nurses. For most products authorized in Europe, instructions for use recommend that patients experiencing an acute respiratory tract infection should temporarily discontinue AIT treatment until the infection is resolved. We recommend taking similar action in COVID-19. Confirmed cases should discontinue AIT, both SCIT and SLIT, independent of disease severity until the symptoms have completely resolved and/or an adequate quarantine has been performed. The possibility of expanding injection intervals in the continuation phase may be beneficial. In patients, who recovered from COVID-19 or who are found to have a sufficient SARS-CoV-2 antibody response after (asymptomatic) disease,14 AIT can be started or continued as planned. AIT can also be continued as usual in patients without clinical symptoms and signs of COVID-19 or other infections and without a history of exposure to SARS-CoV-2 or contact to COVID-19 confirmed individuals within the past 14 days. SLIT offers the possibility of taking it at home, thus avoiding the need to travel to or stay in an allergy clinic or doctor's office, which would be associated with a risk of infection. LK declares grants and/or personal fees from Allergopharma, MEDA/Mylan, LETIPharma, Sanofi, HAL Allergie, Allergy Therapeutics, ALK Abelló, Stallergenes, Quintiles, ASIT biotech, Lofarma, AstraZeneca, GSK, Inmunotek, and is a current member of the AeDA, DGHN, Deutsche Akademie fürAllergologie und KlinischeImmunologie, HNO-BV GPA, and EAACI. MJ reports personal fees from ALK-Abelló, Allergopharma, Stallergenes, Anergis, Allergy Therapeutics, Circassia, LETIPharma, Biomay, HAL Allergy, AstraZeneca, GSK, Novartis, Teva, Vectura, UCB, Takeda, Roche, Janssen, Medimmune, and Chiesi. CA reports grants from Allergopharma, Idorsia, Swiss National Science Foundation, Christine Kühne-Center for Allergy Research and Education, European Commission's Horizon's 2020 Framework Programme, Cure, Novartis Research Institutes, AstraZeneca, SciBase, and advisory role in Sanofi/Regeneron. JB reports personal fees from Chiesi, Cipla, Hikma, Menarini, Mundipharma, Mylan, Novartis, Purina, Sanofi-Aventis, Takeda, Teva, Uriach, and others from KYomed INNOV. CB has received fees for delivering lectures. IA declares personal fees from Mundipharma, ROXALL, Sanofi, MSD, Faes Farma, Hikma, UCB, and AstraZeneca. B-A reports grants and/or personal fees from TEVA, AstraZeneca, Boehringer Ingelheim, GSK, Sanofi, and Mylan. AC reports grants and/or personal fees from GSK, AstraZeneca, Mylan Pharma, Boehringer Ingelheim, and Sanofi. TH reports personal fees from GSK, Mundipharma, and Orion Pharma. J-CI received personal fees from Eurofarma Argentina, Faes Farma, and nonfinancial support from Laboratorio Casasco Argentina and Sanofi. PK has received personal fees from Adamed, Berlin Chemie Menarini, AstraZeneca, Boehringer Ingelheim, Chiesi, Lekam, Novartis, Orion, Polpharma, and Teva. DL-L reports personal fees and/or grants from Allakos, Amstrong, AstraZeneca, Boehringer Ingelheim, Chiesi, DBV Technologies, Grünenthal, GSK, MEDA, Menarini, MSD, Novartis, Pfizer, Sanofi, Siegfried, UCB, Gossamer, TEVA, Boehringer Ingelheim, and the Purina institute. JM declares fees and/or grants from Sanofi-Genzyme, Regeneron, Novartis, Allakos grants, Mylan Pharma, Uriach Group, Mitsubishi-Tanabe, Menarini, UCB, AstraZeneca, GSK, and MSD. RN serves in the speaker's bureau for Optinose and as consultant/advisory board for Sanofi, Regeneron, GSK, and AstraZeneca. YO reports personal fees and/or grants from Shionogi Co., Ltd., Torii Co., Ltd., GSK, MSD, EizaiCo.,Ltd., Kyorin Co., Ltd., Tiho Co., Ltd., Yakuruto Co., Ltd., and Yamada Bee Farm. NP has received personal fees and/or grants from Novartis, Nutricia, HAL Allergy, Menarini/Faes Farma, Sanofi, Mylan/MEDA, Biomay, AstraZeneca, GSK, MSD, ASIT biotech, Boehringer Ingelheim, Gerolymatos International SA, and Capricare. OP reports grants and/or personal fees from ASIT Biotech Tools SA, Laboratorios LETI/LETI Pharma, Anergis SA, ALK-Abelló, Allergopharma, Stallergenes Greer, HAL Allergy Holding BV/HAL Allergie GmbH, BencardAllergie GmbH/Allergy Therapeutics, Lofarma, Biomay, Circassia, MEDA Pharma/Mylan, Mobile Chamber Experts (a GA2LEN Partner), Indoor Biotechnologies, GSK, Astellas Pharma Global, EUFOREA, ROXALL, Novartis, and Sanofi Aventis. JS reports personal fees from Mylan. MHS has received grants and/or personal fees from ALK, Allergopharma, ASIT Biotech, Regeneron, Merck, Immune Tolerance Network. TZ serves as a member of the WHO-Initiative "Allergic Rhinitis and Its Impact on Asthma" (ARIA), the for Allergy and Clinical Immunology head of the European Centre for Allergy Research of the Allergy and European and serves in the on Allergy and World Allergy Organization other have no of within the of the The is not responsible for the or of any supporting information by the than should be to the for the

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