An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype
Allergy2021Vol. 77(4), pp. 1204–1215
Citations Over TimeTop 10% of 2021 papers
Michael Fricker, Ling Qin, Stephany Sánchez‐Ovando, Jodie L. Simpson, Katherine J. Baines, Carlos Riveros, Hayley A. Scott, Lisa G. Wood, Peter Wark, Nazanin Zounemat Kermani, Kian Fan Chung, Peter G. Gibson
Abstract
We demonstrate a pathophysiologically relevant sputum macrophage transcriptomic programme in NA. The finding that there is transcriptional activation of inflammatory programmes in cell types other than neutrophils supports the concept of NA as a specific endotype.
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