Real‐world biologics response and super‐response in the International Severe Asthma Registry cohort
Allergy2024Vol. 79(10), pp. 2700–2716
Citations Over TimeTop 10% of 2024 papers
Eve Denton, Mark Hew, Matthew Peters, John W. Upham, Lakmini Bulathsinhala, Trung N. Tran, Neil Martin, Céline Bergeron, Mona Al‐Ahmad, Alan Altraja, Désirée Larenas‐Linnemann, Ruth Murray, C.A. Celis-Preciado, Riyad Al‐Lehebi, Manon Belhassen, Mohit Bhutani, Sinthia Bosnic‐Anticevich, Arnaud Bourdin, Guy Brusselle, John Busby, Giorgio Walter Canonica, Enrico Heffler, Kenneth R. Chapman, Jérémy Charriot, George Christoff, Li Ping Chung, Borja G. Cosío, Andréanne Côté, Richard W. Costello, Breda Cushen, James Fingleton, João Fonseca, Peter G. Gibson, Liam G. Heaney, Wan‐Chun Huang, Takashi Iwanaga, David J. Jackson, Mariko Siyue Koh, Lauri Lehtimäki, Jorge Máspero, Bassam Mahboub, Andrew Menzies‐Gow, Patrick Mitchell, Nikolaos G. Papadopoulos, Andriana Ι. Papaioannou, Luis Pérez de Llano, Diahn‐Warng Perng, Paul Pfeffer, Todor A. Popov, Celeste Porsbjerg, Chin Kook Rhee, Nicolás Roche, Mohsen Sadatsafavi, Sundeep Salvi, Johannes Martin Schmid, Chau‐Chyun Sheu, Concetta Sirena, Carlos A. Torres‐Duque, Laila Salameh, Pujan H. Patel, Charlotte Suppli Ulrik, Eileen Wang, Michael E. Wechsler, David Price, the ISAR LUMINANT Working Group
Abstract
Most patients with severe asthma are ineligible for RCTs of biologic therapies. Biologics are initiated in patients who have worse baseline impairments than non-initiators despite similar biomarker levels. Although biologic initiators exhibited clinical responses and super-responses in all outcome domains, 40-50% did not meet the response criteria.
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