Role and correlation of exosomes and integrins in bone metastasis of prostate cancer

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Abstract

Prostate cancer (PCa) is one of the most prevalent tumours of the male genitourinary system in the world. In recent years, the morbidity of PCa is steadily rising annually in China. Prostate cancer is prone to distant metastasis, and the most significant complication among patients with advanced PCa is bone metastases. Most patients with prostate cancer do not die of the primary tumour, but more due to the factors of distant metastasis of organs, especially bone metastasis. Due to the lack of effective prevention and monitoring of bone metastasis of PCa in clinical settings, and the lack of effective treatment for patients with bone metastasis, the prognosis of patients is often poor. Therefore, early prevention, early detection, and inhibition of bone metastasis are particularly important. At present, many studies have found that exosomes and integrins are closely related to bone metastasis of prostate cancer, but they have not been summarized together. This review summarizes the literature on the effects of exosomes and integrins on bone metastasis of prostate cancer in recent years. It aims to find more effective ways to prevent, monitor, and treat prostate cancer from the relationship between them.

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