Aberrant acetylation caused by a CDYL splicing mutation contributes to thin mid‐piece related asthenoteratozoospermia and male infertility
Andrology2025Vol. 13(8), pp. 2091–2100
Fan Yang, Yang Gao, Bing Han, Wen Zhu, Guanxiong Wang, Liting Liu, Qunshan Shen, Bing Song, Mingrong Lv, Huan Wu, Dongdong Tang, Ping Zhou, Zhaolian Wei, Yuping Xu, Cao Yun-xia, Xiaojin He
Abstract
We demonstrated that a homozygous CDYL splicing mutation specifically induces a decrease in microtubule acetylation, resulting in thin mid-piece related asthenoteratozoospermia, providing a novel marker for genetic counseling and diagnosis of male infertility.
Related Papers
- → <p>Some of the Factors Involved in Male Infertility: A Prospective Review</p>(2020)274 cited
- → Male Infertility and Its Causes in Human(2011)85 cited
- → Relationship between hemoglobinopathies and male infertility: a scoping review(2024)4 cited
- → New perspectives in male infertility(2017)2 cited
- → Male infertility and gene defects(2010)