The greater incidence of small‐for‐gestational‐age newborns after gonadotropin‐stimulated in vitro fertilization with a supraphysiological estradiol level on ovulation trigger day
Acta Obstetricia Et Gynecologica Scandinavica2019Vol. 98(12), pp. 1575–1584
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Alexandra Kohl Schwartz, Vera Ruth Mitter, Sofia Amylidi‐Mohr, P Fasel, M Minger, Costanzo Limoni, Marcel Zwahlen, Michael von Wolff
Abstract
We found an associated risk of children being born small-for-gestational-age after conventional gonadotropin-stimulated in vitro fertilization compared with natural cycle in vitro fertilization. This higher risk is significantly associated with supraphysiological estradiol levels. We propose a reduction in the dosage of gonadotropin to minimize the risk of small-for-gestational-age and future health consequences.
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