Combined oral contraceptives containing estradiol valerate vs ethinylestradiol on coagulation: A randomized clinical trial
Acta Obstetricia Et Gynecologica Scandinavica2022Vol. 101(10), pp. 1102–1111
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Annina Haverinen, Kaisu Luiro, Tímea Szántó, Marika Kangasniemi, Leena Hiltunen, Susanna Sainio, Terhi Piltonen, Riitta Lassila, Juha S. Tapanainen, Oskari Heikinheimo
Abstract
Both in vitro and in vivo thrombin generation was lower after exposure to EV + DNG compared with EE + DNG. The lower thrombin generation measures after treatment with EV + DNG indicate less enhancement of coagulation potential and suggest that EV may be favorable to EE as a component of combined oral contraceptives.
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