The effects of probiotics on barrier function and mucosal pouch microbiota during maintenance treatment for severe pouchitis in patients with ulcerative colitis
Alimentary Pharmacology & Therapeutics2013Vol. 38(7), pp. 772–783
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Mats Persborn, Jacoline Gerritsen, Conny Wallon, Anders H. Carlsson, L. M. A. Akkermans, J D Söderholm
Abstract
Probiotics restored the mucosal barrier to E. coli and HRP in patients with pouchitis, a feasible factor in prevention of recurrence during maintenance treatment. Restored barrier function did not translate into significant changes in mucosal microbiota composition, but bacterial diversity correlated with barrier function.
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