Serotonergic reinforcement of intestinal barrier function is impaired in irritable bowel syndrome
Alimentary Pharmacology & Therapeutics2014Vol. 40(4), pp. 392–402
Citations Over TimeTop 10% of 2014 papers
Dániel Keszthelyi, Freddy J. Troost, Daisy Jonkers, Hans M. van Eijk, Patrick Lindsey, Jan P. Dekker, Wim A. Buurman, Ad Masclee
Abstract
Oral 5-HTP induced alterations in mucosal 5-HT metabolism. In healthy controls, a reinforcement of the intestinal barrier was seen whereas such reaction was absent in IBS patients. This could indicate the presence of a serotonin-mediated mechanism aimed to reinforce intestinal barrier function, which seems to dysfunction in IBS patients.
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