High risk of drug‐induced microscopic colitis with concomitant use of NSAIDs and proton pump inhibitors
Alimentary Pharmacology & Therapeutics2016Vol. 43(9), pp. 1004–1013
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Bas Verhaegh, Frank de Vries, Ad Masclee, Ali Keshavarzian, Anthonius de Boer, Patrick C. Souverein, Marieke Pierik, Daisy Jonkers
Abstract
Current exposure to NSAIDs, PPIs or SSRIs and prolonged use for 4-12 months increased the risk of MC. Concomitant use of NSAIDs and PPIs showed the highest risk of MC. Acid suppression related dysbiosis may contribute to the PPI effect, which may be exacerbated by NSAID-related side-effects.
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