Systematic review with meta‐analysis: placebo rates in induction and maintenance trials of Crohn's disease
Alimentary Pharmacology & Therapeutics2017Vol. 45(8), pp. 1021–1042
Citations Over TimeTop 10% of 2017 papers
Vipul Jairath, Guangyong Zou, Claire E. Parker, J MacDonald, Mahmoud Mosli, Turki AlAmeel, Mohammad Al Beshir, Majid A. Almadi, Talal Al-Taweel, Nathan Atkinson, Sujata Biswas, Thomas Chapman, Parambir S. Dulai, Mark A. Glaire, Daniël R. Hoekman, Omar Kherad, Andreas Koutsoumpas, Elizabeth Minas, Sophie Restellini, Mark Samaan, Reena Khanna, Barrett G. Levesque, Geert D’Haens, William J. Sandborn, Brian G. Feagan
Abstract
Placebo rates vary according to whether trials are designed for induction or maintenance and the factors influencing them differ for the endpoints of remission and response. These findings have important implications for clinical trial design in Crohn's disease.
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