Systematic review with meta‐analysis: risk factors for thiopurine‐induced leukopenia in IBD
Alimentary Pharmacology & Therapeutics2019Vol. 50(5), pp. 484–506
Citations Over TimeTop 10% of 2019 papers
Sara van Gennep, Kadère Konté, Berrie Meijer, Martijn W. Heymans, Geert D’Haens, Mark Löwenberg, Nanne K.H. de Boer
Abstract
TPMT and NUDT15 variants predict thiopurine-induced leukopenia. High 6-TGN and 6-MMP levels might induce leukopenia, although exact cut-off values remain unclear. Potential preventive measures to reduce the risk of thiopurine-induced leukopenia include pre-treatment TPMT and NUDT15 genotyping. Routine thiopurine metabolite measurement might be efficient, yet cut-off levels must be validated in advance.
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