Randomised, placebo‐controlled trial and meta‐analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The TRITON trial
Alimentary Pharmacology & Therapeutics2023Vol. 57(11), pp. 1258–1271
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David Gunn, Rabia Topan, Lorna Barnard, Ron Fried, Ivana Holloway, Richard Brindle, Maura Corsetti, S. Mark Scott, Adam D. Farmer, Kapil Kapur, David S. Sanders, Maria Eugenicos, Nigel Trudgill, Peter J. Whorwell, John McLaughlin, Ayesha Akbar, Lesley A. Houghton, Phil G. Dinning, Qasim Aziz, Alexander C. Ford, Amanda Farrin, Robert E. Spiller
Abstract
Although small numbers meant the primary endpoint was not met in this trial, when pooled with other similar trials meta-analysis suggests ondansetron improves stool consistency and reduces days with loose stool and urgency. Trial registration - http://www.isrctn.com/ISRCTN17508514.
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