Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents
British Journal of Clinical Pharmacology2015Vol. 80(5), pp. 1185–1196
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Anne van Rongen, Janelle D. Vaughns, Ganesh S. Moorthy, Jeffrey S. Barrett, Catherijne A. J. Knibbe, Johannes N. van den Anker
Abstract
The pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents show a marked increase in peripheral volume of distribution and a lack of influence on clearance. The findings may imply a need for a higher initial infusion rate upon initiation of a continuous infusion in obese adolescents.
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