Pharmacokinetic–pharmacodynamic modelling of neutrophil response to G‐CSF in healthy subjects and patients with chemotherapy‐induced neutropenia
British Journal of Clinical Pharmacology2018Vol. 84(5), pp. 911–925
Citations Over TimeTop 16% of 2018 papers
Murad Melhem, Isabelle Delor, Juan José Pérez Ruixo, John M. Harrold, Andrew Chow, Liviawati S. Wu, Philippe Jacqmin
Abstract
This qualified model simulates the time course of ANC in the absence or presence of chemotherapy and predicts nadir, time to nadir and time of recovery from different grades of neutropenia upon treatment with filgrastim and pegfilgrastim.
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