Neuroprogression and episode recurrence in bipolar I disorder: A study of gray matter volume changes in first‐episode mania and association with clinical outcome
Bipolar Disorders2016Vol. 18(6), pp. 511–519
Citations Over TimeTop 10% of 2016 papers
Jan‐Marie Kozicky, Alexander McGirr, David J. Bond, Marjorie Gonzalez, Leonardo Evangelista da Silveira, Kamyar Keramatian, Ivan J. Torres, Raymond W. Lam, Lakshmi N. Yatham
Abstract
GMV change early in the course of BD-I is associated with clinical outcome, such that neuroprogression found in patients who experience a recurrence of a mood episode is not seen in those with sustained remission. These findings have important implications for the treatment of BD-I as they suggest that prevention of recurrence might minimize neuroprogression of the disease, possibly requiring a multipronged early intervention approach to achieve this goal.
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