Regulated genes in psoriatic skin during treatment with fumaric acid esters
British Journal of Dermatology2014Vol. 171(4), pp. 732–741
Citations Over TimeTop 12% of 2014 papers
Armanda J. Onderdijk, Deepak Balak, Ewout M. Baerveldt, Edwin F. Florencia, Marius Kant, Jon D. Laman, Wilfred F. J. van IJcken, Emöke Rácz, De Ridder, Hok Bing Thio, Errol P. Prens
Abstract
FAE treatment induces glutathione and Nrf2 pathway genes in lesional skin of patients with psoriasis. In responders, FAEs specifically regulate the transcription factors PTTG1, NR3C1, GATA3 and NFκBIZ, which are important in normal cutaneous development, and the T-helper (Th)2 and Th17 pathways, respectively.
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