Dysregulated cytokine expression in lesional and nonlesional skin in hidradenitis suppurativa
British Journal of Dermatology2015Vol. 173(6), pp. 1431–1439
Citations Over TimeTop 1% of 2015 papers
G. Kelly, Rosalind Hughes, Trudy McGarry, Marise Ph. Born, K. Adamzik, R. Fitzgerald, C. Lawlor, Anne‐Marie Tobin, Cheryl Sweeney, Brian Kirby
Abstract
This study demonstrates that CD4(+) T cells produce IL-17 in HS and that the IL-17 pathway may be important in HS pathogenesis. CD11c(+) CD1a(-) CD14(+) cells are a source of IL-1β in HS, the production of which was shown to be mediated, in part, via a caspase-1-dependent pathway. These results suggest that IL-17 and the caspase-1-associated cytokines IL-1β and IL-18 may play a role in the pathogenesis of HS.
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