The genetic basis for most patients with pustular skin disease remains elusive
British Journal of Dermatology2017Vol. 178(3), pp. 740–748
Citations Over TimeTop 10% of 2017 papers
Rotraut Mößner, Dagmar Wilsmann‐Theis, Vinzenz Oji, Paraskevi Gkogkolou, Sabine Löhr, Peter Schulz, Andreas Körber, Jörg C. Prinz, Regina Renner, Knut Schäkel, Elisabeth Vogelsang, Kathrin Peters, Sandra Philipp, Kristian Reich, Hartmut Ständer, Arnd Jacobi, Ansgar Weyergraf, Külli Kingo, Sulev Kõks, Sascha Gerdes, Kirsten Steinz, Tillmann Schill, Klaus Griewank, Michael Müller, Silke Frey, L. Ebertsch, Steffen Uebe, Michael Sticherling, Heinrich Sticht, Ulrike Hüffmeier
Abstract
The identification of IL36RN mutation carriers harbouring additional rare variants in CARD14 or AP1S3 indicates a more complex mode of inheritance of pustular psoriasis. Our results suggest that, in heterozygous IL36RN mutation carriers, there are additional disease-causing genetic factors outside IL36RN.
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