Methotrexate restores the function of peripheral blood regulatory T cells in psoriasis vulgaris via the CD73/AMPK/mTOR pathway
British Journal of Dermatology2018Vol. 179(4), pp. 896–905
Citations Over TimeTop 12% of 2018 papers
Abstract
We speculate that MTX can restore the immunosuppressive function of Tregs through upregulating CD73, activating AMPK and inactivating the mTOR pathway. These findings may partly explain the mechanism by which MTX treats psoriasis.
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