Differential expression of secreted factors SOSTDC 1 and ADAMTS 8 cause profibrotic changes in linear morphoea fibroblasts
British Journal of Dermatology2018Vol. 180(5), pp. 1135–1149
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Irbaz I. Badshah, Stuart J. Brown, Lisa Weibel, Aidan Rose, Benjamin Way, Neil J. Sebire, Gareth J. Inman, JI Harper, Ryan F.L. O’Shaughnessy
Abstract
We demonstrate that cell-intrinsic changes in the LM fibroblast secretome lead to changes observed in the disease, and that secretome modulation could be a viable therapeutic approach in the treatment of LM.
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