Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels
British Journal of Pharmacology2012Vol. 168(6), pp. 1294–1312
Citations Over TimeTop 10% of 2012 papers
Xin Qin, Zhichao Yue, Baonan Sun, Wudao Yang, Jia Xie, Eric Ni, Feng Yi, Rafat Mahmood, Yanhui Zhang, Lixia Yue
Abstract
This is the first study demonstrating that SPH and FTY720 are potent inhibitors of TRPM7. Our results not only provide a new modulation mechanism of TRPM7, but also suggest that TRPM7 may serve as a direct target of SPH and FTY720, thereby mediating S1P-independent physiological/pathological functions of SPH and FTY720.
Related Papers
- → Biophysics of sphingolipids I. Membrane properties of sphingosine, ceramides and other simple sphingolipids(2006)267 cited
- → Biophysical properties of sphingosine, ceramides and other simple sphingolipids(2014)57 cited
- → Role of sphingosine kinase localization in sphingolipid signaling(2010)31 cited
- → Role of Sphingolipids in Bacterial Infections(2020)1 cited
- → Signal transduction by sphingosine kinase(1999)1 cited