Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3
British Journal of Pharmacology2012Vol. 168(8), pp. 1835–1850
Citations Over TimeTop 12% of 2012 papers
Isabelle Straub, Florian Mohr, Julia Stäb, Moira Konrad, Stephan Philipp, Johannes Oberwinkler, Michael Schaefer
Abstract
The data indicate that citrus fruit flavonoids are potent and selective blockers of TRPM3. Their potencies ranged from upper nanomolar to lower micromolar concentrations. Since physiological functions of TRPM3 channels are still poorly defined, the development and validation of potent and selective blockers is expected to contribute to clarifying the role of TRPM3 in vivo. Considering the involvement of TRPM3 in nociception, TRPM3 blockers may represent a novel concept for analgesic treatment.
Related Papers
- → Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse(2004)193 cited
- → Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8(2015)72 cited
- → Targeting temperature-sensitive transient receptor potential channels in hypertension: far beyond the perception of hot and cold(2023)5 cited
- → Vanilloid (TRPV1) and Other Transient Receptor Potential Channels(2009)2 cited