Inhibitory cross‐talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress‐induced insulin resistance in skeletal muscle
British Journal of Pharmacology2013Vol. 169(1), pp. 69–81
Citations Over TimeTop 10% of 2013 papers
Seung‐Lark Hwang, Yong‐Tae Jeong, Xian Li, Yong Deuk Kim, Yue Lu, Young‐Chae Chang, In‐Kyu Lee, Hyeun Wook Chang
Abstract
Inhibition of ERK signalling pathways by a chemical inhibitor and knockdown of ERK improved AMPK and Akt signallings and reversed ER stress-induced insulin resistance in L6 myotubes. These findings suggest that ERK signalling plays an important role in the regulation of insulin signals in muscle cells under ER stress.
Related Papers
- → Modeling Acute ER Stress in Vivo and in Vitro(2016)120 cited
- → Klotho Ameliorates Chemically Induced Endoplasmic Reticulum (ER) Stress Signaling(2013)49 cited
- → The regulatory mechanism of 4-phenylbutyric acid against ER stress-induced autophagy in human gingival fibroblasts(2012)46 cited
- ER Stress에 의해 유발된 C6 Glial Cells의 손상에 대한 龍腦의 보호효과(2009)
- Inhibition of CaMKII Suppresses the Endoplasmic Reticulum Stress-induced Cardiomyocytes Death in Rats(2009)