A GPR18‐based signalling system regulates IOP in murine eye
British Journal of Pharmacology2013Vol. 169(4), pp. 834–843
Citations Over TimeTop 10% of 2013 papers
Meggie D. Caldwell, Sherry Shu‐Jung Hu, Suresh Viswanáthan, Heather B. Bradshaw, Michael E. Kelly, Alex Straiker
Abstract
We present evidence for a functional GPR18-based signalling system in the murine anterior eye, including receptors and ligands. GPR18 agonists, Abn-CBD and NAGly, reduce IOP independently of CB₁, CB₂ or GPR55. These findings suggest that GPR18 may serve as a desirable target for the development of novel ocular hypotensive medications.
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