Beneficial effects of a novel agonist of the adenosine A2A receptor on monocrotaline‐induced pulmonary hypertension in rats
British Journal of Pharmacology2013Vol. 169(5), pp. 953–962
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A Alencar, Sharlene Lopes Pereira, Tadeu L. Montagnoli, Rodolfo do Couto Maia, Arthur Eugen Kümmerle, Sharon Schilling Landgraf, Celso Caruso‐Neves, Emanuelle Baptista Ferraz, Roberta Tesch, José Nascimento, Carlos M.R. de Sant’Anna, Carlos Alberto Manssour Fraga, Eliezer J. Barreiro, Roberto T. Sudo, Gisele Zapata‐Sudo
Abstract
In rats with MCT-induced PAH, structural and functional changes in heart and pulmonary artery were reversed by treatment with oral LASSBio-1359, most probably through the activation of adenosine A2A receptors.
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